The Study on the Effect of Nano-selenium on Oogenesis and Uterus Changes in Adult NMRI Mouse Strain

Different nutrients with effects on male reproductive organs have a significant effect on the prevention and treatment of infertility, one of these elements is selenium. The goal of this study was to evaluate selenium nanoparticles (NSAs) in oogenesis and uterine changes in adult female NMRI mice.In this study, 30 adult female NMRI mice were selected and randomly divided into five groups: controls, Sham and 3 experimental groups. Control group did not receive any material, the sham group received solvent and the experimental groups received nano selenium in 3 doses of 0.2 mg/kg, 0.3 mg/kg, 0.4 mg/kg for 30 days. The weight of the animals in the experimental groups at the high dose was significantly reduced. The weight and diameter of the ovary declined so that the results were not significant. The number of primordial follicles, primary and secondary follicles, and atretic follicle have decreased. The number of Graafian follicles decreased at a dose of 0.4 mg/kg of nano selenium and also corpus luteum in a dose of 0.3 mg/kg of nano selenium decreased. The diameter of the secondary follicle was increased, but not significant. The diameter of the Graafian follicle did not change. The number of blood vessels in the ovaries was increased, but the diameter of them did not change significantly. In experimental groups, the diameter of the uterine cavity was significantly reduced. The thickness of the perimetrium of uterine layer was reduced. The number of uterine glands endometrium decreased in the third experimental group, but their diameter did not significantly change in any of the groups. Nano-selenium caused an increase in the number of primordial, primary and secondary follicles due to its antioxidant effect, and the uterine layer of the endometrium increased and perimetrium and myometrium decreased.