Vitamin E deficiency and cardiovascular diseases

Aim:  This study reviews the role of vitamin E in cardiovascular diseases. Cardiovascular diseases are among the most common health-related problems, and the number of the patients with cardiovascular diseases increases each year. Long-term manifestations of cardiovascular disease bears a lot of cost to the family and society. This review study was conducted by searching out the related literature in the databases Google Scholar, PubMed, PMC, Springer, and Elsevier, for papers published from 2014 to 2018. Initially, a total of 72 articles were found and the number of articles was reduced to 42 by removing duplicates and articles that were only accessible as abstract. Finally, a review by 21 articles was carried out. α-Tocopherol is the most common form of vitamin E in human tissues. Increased oxidative stress is an important mediator of endothelial injury in hypertension pathology, associated with increased oxidant protein production, such as hydrogen peroxide super oxidation, decreased nitric oxide synthesis, and decreased biological capacity of antioxidants. Oxidative stress may lead to endothelial dysfunction, inflammation, hypertrophy, fibrosis, and angiogenesis associated with hypertensive vascular changes. Vitamin E deficiency can provide a constraint for micro ribonucleic acids (miRNAs) networks, and this may lead to the progression of atherosclerosis. Vitamin E deficiency causes adverse effects in cardiovascular systems. However, the effect of its use in the treatment of diseases is still not fully understood. A good amount of Vitamin E should be provided and it should be replaced before the complications occur.