The Effect of Endurance Exercise Training on the Balance of Perinatal Stressed Parkinson Rats

Parkinson's disease is a disorder in the nervous system due to the degeneration of dopaminergic neurons. Dopaminergic system is susceptible to neurological disorders caused by exposure to stressors early. Positive experiences are one of the most powerful treatments to increase neuroplasticity and motor function at any time of life. The purpose of the present study was to investigate the effect of pre-treatment endurance training on the balance of Parkinson's rats with perinatal stress. In the present experimental study, 48 neonates rats of 30 days of age, with half of them under perinatal stress, were randomly divided into 8 groups consistening of no stress groups (control, sham, parkinson, endurance training + Parkinson's) and stress groups (control, Sham, Parkinson's, Endurance Exercise + Parkinson's). After 8 weeks of endurance training, stereotoxic surgery was performed on mice to create a Parkinson's model. After three weeks, theapomorphine test was used for diagnosis of Parkinson's disease and balance beam equilibrium test. Data were analyzed by one-way ANOVA and Tukey's post hoc test. The results indicated that the endurance exercises improved balance in both groups with and without prenatal stress(p<0.05). Furthermore, prenatal stress reduced balance, but this reduction was not significant(p=0.059), and perinatal stress also reduced the beneficial effects of exercise on balance test(p <0.05). According to the findings, perinatal stress seems to reduce the balance of Parkinson's rats and endurance exercises reduce the negative effects of perinatal stress, which leads to a reduction in the negative effects of Parkinson's on balance.