Comparison of the effect of thiopental sodium-midazolam combination on the hemodynamic response between tracheal intubation and laryngeal mask airway insertion: A clinical trial study

The purpose of this study was to compare the effect of thiopental sodium-midazolam combination on the stress response and hemodynamic changes between tracheal intubation and laryngeal mask airway insertion during airway management. In this clinical trial study, 70 patients ASA 1, 2 candidates for elective surgery were randomly divided into two groups of tracheal intubation and laryngeal airway mask insertion. Hemodynamic variables including mean arterial pressure, heart rate, and arterial oxygen saturation were measured and compared between the two groups before and after intubation. There was no significant difference between the two groups in regard to demographic data (age, sex, height, and weight), heart rate, mean arterial pressure and arterial oxygen saturation at 1 and 3 minutes after induction of anesthesia and 1, 3, 5 and 10 minutes after intubation. (P> 0.05). But there were significant differences between the two groups in relation to heart rate at 1 and 3 minutes after intubation, so that heart rate at these times was significantly higher in the intubation group than in the laryngeal airway mask group (P <0.05). Based on the findings of this study, use of thiopental sodium midazolam combination was effective and safe and attenuated the stress response to airway management with resultant minimal changes in the heart rate and blood pressure.