Effects of omega 3 and vitamin E supplementation on Gene Expression of SIRT1, hTERT and serum level of hsCRP in CAD male patients: a randomized clinical trial study

Studies have shown that Sirtuins have critical roles in the regulation of inflammation and oxidative stress, while hTERT has a protective effect via increasing the length of telomers in cardiovascular disease. The aim of this study was to assess the effects of omega 3 and vitamin E supplementation on the gene expressions of SIRT1 and hTERT and serum hsCRP level in CAD patients.

Participants in this Randomized Clinical Trial consisted of 60 non-smoking male CAD patients, with age ranges 45- 65 years, who were categorized into three groups, receiving: 4g/day of omega 3 and vitamin E placebo (OP); omega 3 (4g/day) and vitamin E 400IU/day (OE); and omega 3 and vitamin E placebos (PP) for two months.

Gene expression of SIRT1 increased significantly in the OE group (P = 0.039), but gene expression of hTERT was not significantly different between the study groups. Supplementation with omega 3 and also co-administration of these fatty acids with vitamin E significantly decreased hsCRP level in OP and OE groups (P=0.008 and P= 0.050, respectively).

Supplementation with omega 3 and vitamin E seems to include beneficial effects on CAD patients, possibly via increasing gene expression of SIRT1, and also by lowering inflammation through decreasing serum level of hsCRP in these patients.