Effect of 8 weeks endurance training on omentin-1 gene expression of visceral adipose tissue in Streptozotocin-induced diabetic male rats

Diabetes is a health problem in all societies, and exercise training is one of the best method to control blood glucose levels. The aim of this study was to investigate the effect of 8 weeks of endurance training on omentin-1 gene expression of visceral adipose tissue in diabetic male rats.

Among 19 male rats 6 mice were randomly selected as controls basic group. The remaining rats were given a high-fat diet and free access to food and water and then diabetes was induced by Streptozotocin. Diabetic rats were divided into two groups including endurance training (n=6) and control (n=7) groups. Endurance training exercised on a treadmill up to 50 to 70 percent of maximal oxygen uptake, 5 days per week for 8 weeks based on the overload pattern. After 8 weeks, samples of visceral adipose tissue were collected and omentin-1 gene expression determined using RT-PCR method. It is applied the ANOVA and Tukey post hoc tests for extracted of results using SPSS software at the significant level of p

There were no significant differences in the weight of rats in baseline and after 8 weeks of endurance training (p>0.05). However, omentin-1 gene expression significantly increased after continuous endurance training (p<0.001).

Based on omentin-1 gene expression improvement and its role to activation of AKT pathway and glucose uptake elevation by adipose tissue, it seems that this adipokine have an important effect in lowering blood sugar in diabetic patients.