The Peritoneal Membrane’s Transportation Characteristics In Chronic Peritoneal Dialysis Patients At The Start Of Dialysis

As evaluation of peritoneal membrane function is important in prescribing and choosing the kind of peritoneal dialysis and probability of difference in peritoneal membrane  characteristics among patients belonging to different geographical areas and different ethnic origin, also the possible impact of the type of transportation on patient survival,  we used peritoneal equilibration test (PET) to determine the kind of peritoneal membrane transportation at the start of dialysis.

Forty  CAPD (continuous ambulatory peritoneal dialysis)patients, (30 males and10 females,  with a mean age of 38 ± 14 years) attending Ghaem hospital, Mashhad, Iran, between October 2004 and October 2018, entered in to this study and underwent a 4.25% glucose, PET test.

The obtained result showed that about 90% of patients were high or high average transporters. The results were completely different from  the results reported from other world’s peritoneal dialysis centers, which have reported between 35 to 55 percent of high or high average transporters among chronic peritoneal dialysis patients. Using a glucose correction factor formula, proposed by Twardowski, about thirty years ago, which only partially resolves the accuracy and precision problems, is the probable cause of this disparity.

In our center, about 90% of chronic peritoneal dialysis patients on CAPD, at the start of dialysis, were high or high average transporters. These results are in complete discordance with results reported in  medical literature or from other parts of the world. Using an outdated, glucose correction factor, with significant  residual error may be the source of this discrepancy.