A comparative study on the effect of heparin on of intermittent intravenous injection and continuous infusion with syringe pump on APTT results and possible complications in patients with acute coronary syndrome

Ischemic heart disease is the first cause of early death in the world. One of the main treatments for patients with acute coronary syndrome is the use of anticoagulants. The aim of this study, The aim of this study was to compare effect of two methods of intermittent intravenous injection and continuous infusion on APTT in patients with ACS.

clinical trial was performed on 60 patients selected by random sampling in Neishabour Hospital in 2018. To data gathering were used the demographic information questionnaire, and APTT checklist. The intravenous injection group received 2500 units heparin every 3 hours and infusion group was given 1000 units per hour and APTT was controlled. Data analysis was done using SPSS-16 software and sinifiant level was considered to be less than 0.05.

Mean APTT level in first stage was 40.8 ± 11.17 and 38.87 ± 8.86 in intermittent intravenous injection and continuous infusion groups respectively. In the 8th stage, mean APTT level in intravenous injection group was 55.03 ± 8.41 and in continuous infusion group was 55.7 ± 14.09. Independent t-test did not show a significant difference between the two groups (P> 0.05).

Regarding to approximation of the results in two methods, alternate injection method can be used instead of continuous intravenous infusion. This method creates less constraints for the patient and reduces the burden on nurses due to don’t need setting pump syringe, serum heparin preparation, and alleviation of alarms.