The effect of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and population of alveolar epithelial cells

This study investigated the effect of 3-weeks Taper in hypoxic environment on the ratio of Bax / Bcl2 and alveolar epithelial cells populations in the lung.

Thirty-five rats (4 weeks old, weighing 8 ± 72 g) were divided in five groups: control (6 weeks), training (6 weeks), hypoxia (3 weeks), hypoxia - taper (3 weeks) and control (9 weeks). Samples entered to the hypoxia after six weeks of interval training and lived there for 3 weeks. another group with exposure to hypoxic environment , implementation Taper technique.Bax/Bcl2 ratio of lung measured by immunohistochemistry and type II and type I pneumocytes population of pulmonary alveolar measured with stereologically.

Bax/Bcl2 ratio and type II pneumocytes population Increased and type I pneumocytes population Decreased After six weeks high intensity interval training (P≤0.5).Bax/Bcl2 ratio and type I pneumocytes population of hypoxia group decreased compared with training group (P≤0.5). three weeks taper in hypoxia group, Led to decrease of Bax/Bcl2 ratio , type II population pneumocytes and Increase of type I pneumocytes (P≤0.5).

It seems high intensity interval training and subsequent hypoxia can increase pulmonary alveolar apoptosis. also appears taper is a Efficient Method to decrease of apoptosis lung.