The Role of Matrix Metalloproteinase-2 Expression in Gastric Cancer Susceptibility: A Systematic Review
Message:
Abstract:
Context

Gastric carcinoma (GC) is the most commonly diagnosed cancer that has been one of the main causes of cancer death worldwide. The matrix metalloproteinase-2 (MMP2) gene was expressed in the gastric cancer tissues compared to the matched normal tissues that are associated with the metastasis of gastric cancer cells.

Objectives

This systematic review was performed to investigate the role of MMP-2 in gastric cancer among the different population.
Evidence Acquisition: We searched on electronic databases such as PubMed, Scopus, Science Direct and Cochrane Library Database without any language restriction for relevant publications which were published until April 2019.

Results

Thirty two original and relevant studies that evaluate the association between gastric cancer and MMP-2 were included. This systematic review indicated that increased MMP-2 expression has been seen in gastric cancer. MMP-2 over-expression may play a crucial role in degrading extracellular matrix as well as stimulate angiogenesis.

Conclusions

MMP2 over-expression can play a critical role in tumor metastasis, tumor size, invasion, and lymph node invasion in GC

Article Type:
Research/Original Article
Language:
English
Published:
International Journal of Cancer Management, Volume:12 Issue:9, 2019
Page:
1
magiran.com/p2041296  
روش‌های دسترسی به متن این مطلب
اشتراک شخصی
در سایت عضو شوید و هزینه اشتراک یک‌ساله سایت به مبلغ 300,000ريال را پرداخت کنید. همزمان با برقراری دوره اشتراک بسته دانلود 100 مطلب نیز برای شما فعال خواهد شد!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی همه کاربران به متن مطالب خریداری نمایند!