Evaluation of two types of vitamin D receptor gene morphism in patients with type 2 diabetes and obesity

Diabetes is the most common endocrine disorder that affects many people each year. Many people suffer from diabetes and obesity. The effects of renoprotective vitamin D and its analogues in chronic kidney diseases, including diabetic nephropathy, have been reported. The aim of this study was to investigate the rs731236 and rs2228570 polymorphisms of vitamin D receptor gene (GDR) in patients with type 2 diabetes and obesity.

Material & Method:

In this case-control study, 120 patients with type 2 diabetes and 120 healthy controls (control group) referred to Amiralmomenin Arak Hospital were investigated. After collecting clinical data and performing Laboratory tests, DNA samples were extracted from blood samples by phenol chloroform method, and polymorphisms in specimens were examined by specific genotypes. Data were analyzed by SPSS22 software.

There was no correlation between Taq1 and Fok1 polymorphisms with both healthy and healthy patients. Although the frequency of CT genotype was higher in both groups, this difference was not significant (P-Value > 0.05).

No evidence was found that VDR gene polymorphisms play a role in the risk of type 2 diabetes and obesity in Iranian subjects. Further studies in prospective cohort studies should be performed to determine the genome-wide association to evaluate the direct effect of these polymorphisms on type 2 diabetes.