Effect of interval training along with Adiantum capillus-veneris Linn supplemen on surfactant protein (SP-A) in lung male rats

Surfactant protein (SP-A) is most abundant surfactant protein in lungs and plays an important role in eliminating the infection and inflammatory mediators. Further, Adiantum capillus-veneris Linn (Pare-siavashan) composed elements such as flavonoids and saponins maidenhair and may play an effective role in inhibiting the inflammatory responses. The aim of this study was to investigate the effect of interval training along with Adiantum capillus-veneris Linn supplementation on levels of SP-A in lung male rats.

Thirty male Wister rats with three weeks old and average weight of 68 ± 9 g were randomly divided into 2 groups including interval training and control groups. The interval training group was divided into three sub-groups including training, supplementation and training+supplementation groups after the end of 6-week interval .training.  The Adiantum capillus-veneris Linn herbal supplement were fed orally for 3 weeks, with the daily dose of 200 mg per kilogram of body weight.. The levels of lung SP-A was measured using Cusabio ELISA kit (China Company). The data were analyzed using one-way ANOVA and LSD tests at the significant level of p

The results showed no significant differences between lung SP_A levels after 6 (p=0.28) and 9 (p=0.14) weeks of interval training compared to control group; however SP_A significantly decreased in the training - Adiantum capillus-veneris Linn group (P=0.001) compared to other interventions.

Regarding the significant reduction of SP_A after interval training, it seems that supplementation may inhibit the pathophysiological effects of incremental trainings and to reduce the inflammatory parameters well and to strengthen the lung immunity.