The effect of aerobic training and Vitamin Don GPx concentration and PABin lung tissue of rats exposed to Hydrogen Peroxide

Physical activity has various impacts on antioxidant defense, which depends on its intensity and duration. On the other hand, ALSO vitamin D has antioxidant properties. However, the simultaneous effect of these interventions on antioxidants is not well understood. So, the aim of present study was to investigate theeffects of combination of aerobic training and Vitamin Don GPx concentration and oxidant–antioxidant balance (PAB) in lung tissue of rats exposed to Hydrogen Peroxide.

In this experimental study, 30 male Wistar rats weighing 220 ± 20 g, aged 8 -10 weeks were randomly divided into 5 groups of oxygenated water (n = 6), oxygenated water - vitamin D (6 = n), oxygenated water - aerobic exercise (n = 6), oxygenated water - aerobic exercise and vitamin D (n = 6) and healthy control (n = 6) were divided into intervention protocol for 8 weeks and 3 sessions per week. (Induction of oxidative stress, aerobic exercise and vitamin D intake). Research variables were measured by specialized kits and ELISA in lung tissue. Inferential data were analyzed using Shippo-Wilk tests, one-way ANOVA, two-way ANOVA and Bonferroni post hoc test.

The interaction of aerobic training with vitamin D caused increase in GPx and significant decrease in PAB (P>0.05).

According to the results of this study, the combination of aerobic exercise and vitamin D under conditions of induction of oxidative stress can induce improve the antioxidant activity and reduce oxidative stress and has protective effect on lung tissue.