Treatment of vitamin D deficiency with high-dose vitamin D supplementation and its effect on hematological indices in pregnancy: A secondary analysis of a randomized clinical trial

There are few studies regarding the treatment of vitamin D deficiency with a high dose of vitamin D and the comparison of serum vitamin D levels and hematological indices (Hemoglobin, Hematocrit, Platelet and Ferritin) in the first and second trimesters of pregnancy. The aim of this study was to evaluate the effect of vitamin D supplementation on these hematological indices in pregnant women with vitamin D deficiency.

The present study was performed in October 2019 from a secondary and non-predetermined analysis of the effect of vitamin D supplementation and comparison of serum vitamin D levels on blood parameters from a randomized controlled clinical trial. 215 pregnant mothers with vitamin D deficiency were entered in the study and were divided into two treatment groups of 50,000 units and 1000 units.

Mean serum levels of Hematocrit, Platelets, and Ferritin after treatment in the treatment groups with 50000 and 1000 unites were 38.6± 3.03 vs 36.05± 2.8 (P<0.38), 243083 ± 55302 vs 215942 ± 45513 (P<0.29) and 42.3± 33.5 vs 28.8± 21.7 (P<0.04), respectively. The mean Hemoglobin level in the treatment groups with 50,000 and 1000 units were 12.08± 1.17 vs. 12.3± 2.5 (P<0.84), respectively. In both groups, there was a significant relationship between serum vitamin D level, Hemoglobin and Hematocrit levels before treatment. (Respectively P<0.02, P<0.02 and P<0.05). The serum Ferritin level was significantly higher with serum vitamin D after treatment (P<0.04).

This study showed that the results of two therapeutic groups in pregnant women with vitamin D deficiency, especially a dose of 50,000 units of vitamin D, compared to the first trimester of pregnancy, had different effects on the hematologic indices.