The effect of dexamethasone on serum concentrationof some biochemical parameters in dairy cowswith LDA

This study was conducted in order to evaluate the effect of dexamethasone on clinical healing and serum concentration of some biochemical parameters in dairy cows with LDA. 20 dairy cows with LDA were diagnosed and theywere divided into control (10 cows) and treatment groups (10 cows). Operation was carried out and antibiotic wasused in two groups and, in treatment group dexamethasone 0.5 mg.kg was injected once. All cows were examinedand their blood samples were drawn before and fve days after operation. The level of BHBA, ALT, AST, GGT andcalcium in serum samples were measured. After operation, the appetite and defecation returned to normal. In bothgroups, rumen movement increased that was signifcant in treatment group (P<0.05). In treatment group, beforeand after the operation mean serum level of BHBA were 1.24±0.07 and 0.88±0.06 mmol/l, glucose 29.22±2.66 and32.84±2.63 mg/dl, AST 127.57± 7.1 and 97.09±7.46 U/L, ALT 39.68=1.88.7.1 and 22.15±1.82. There was a signifcant difference between means (p= 0.001, p=0.005, p=0.002, p= 0.000, respectively). There was no signifcantdifference between GGT and Ca means. In control group there was no signifcant difference between means. Inconclusion, Injection of dexamothasone after the operation in cows with LDA increases serum level of glucose anddecrease BHBA and liver enzymes.