Effect of mineral water of Kandovan's spring on calcium oxalate kidney stone in adult male rats

Urolithiasis is a worldwide problem, sparing no geographical, cultural, or racial groups. In the present study, effect of Kandovan’s mineral water on calcium oxalate crystallization was studied in adult male rats. Crystallization of calcium oxalate was induced by adding ammonium chloride and ethylene glycol in drinking water for 3 and 35 days, respectively. Control group was treated by drinking water. Experimental group were treated by Kandovan’s mineral water for 38 days. After 38 days, animals were anesthetized by ether and left kidneys removed and put them in buffered formaldehyde. Specimens were prepared for histological studies and stained by H&E. results showed that treatment of Kandovan’s mineral water decreased number of crystals in kidney sections of experimental animals in comparison with control group. Also, administration of mineral water decreased tubule-interstitial damages in treated animals. So, the mineral water could prevent formation of primary nucleus of kidney stones.