Evaluation of the relationship between maternal serum vitamin D level with premature amniotic sac rupture in pregnant women referred to Asalian Hospital in Khorramabad 2019-2020

Vitamin D deficiency is common during pregnancy and childbirth. Recent findings suggest that vitamin D deficiency is associated with adverse pregnancy outcomes. This study was performed to determine the association between low levels of maternal serum vitamin D and some adverse pregnancy outcomes such as premature rupture of embryonic membranes.

73 pregnant women with premature rupture of embryonic membranes as a case group 73 healthy pregnant women as control group were randomly selected from 18 to 35 pregnant women with a gestational age of 28 to 41, who had been referred to Asalian Hospital within 6 months, were selected. Blood levels of vitamin D were measured in both groups. Demographic information as well as data from laboratory results and patient histories were collected using a researcher checklist. Finally, patients were statistically evaluated for vitamin D levels and study factors.

The mean vitamin D level in patients with PROM was 22.49 7 ±7.25nm/lit and the mean vitamin D level in patients without PROM was 28.73 ±8. 8.72nm/l with p = 0.00. There was a significant relationship between vitamin D and PROM levels.

Based on the results of data analysis, it was found that there was a significant relationship between vitamin D levels and premature rupture of the amniotic sac. To examine more closely the relationship between maternal vitamin D levels and the occurrence of premature rupture of embryonic membranes, further research with a larger sample size and complete control of interfering factors is recommended.