The effect of cardiac resynchronization therapy (CRT) on EF improvement in heart failure patients base of patients’ sex

Heart failure is a serious public health problem that leads to frequent hospitalization, reduced quality of life and death. Cardiac resynchronization therapy (CRT) is wealth treatment for heart failure diseases but rate of no response is high.

To evaluate the effect of CRT on EF improvement in heart failure patients base of patients’ sex.

The present study is clinical trial, before and after the intervention, which has been performed on 21 heart failure patients with CRT admitted to Imam Khomeini Hospital of Ahvaz in 2019. Demographic and clinical characteristics of patients were assessed and recorded, and all patients underwent 3D echocardiography before and 2-3 weeks after CRT to assess response to treatment. In all subjects, left ventricular EF were measured when the CRT was switched off and also after switching on the device.

The study subjects were included 12 men (57.1%) and 9 women (42.9%) with a mean age of 64.57±9.99 years. The results showed that the MR intensity index score decreased significantly after the intervention (P=0.002). The mean EF changes before and after CRT intervention were not significant based on patient’s gender (P=0.754) and age (P=0.617).

The results of this study revealed that CRT treatment in patients with heart failure causes a positive clinical response by increasing EF. Moreover, the effect of this treatment and EF changes is independent of patients age and gender. Keywords: heart failure, cardiac resynchronization therapy, Left Ventricular EF, echocardiography