Association of IL-19 Gene Polymorphism (rs2243191T / C) with Occurrence of Preeclampsia in Pregnant Women

Preeclampsia is the most common and at the same time the most unknown pregnancy-related disease, is the leading cause of death in pregnant women worldwide. Increased systemic inflammatory factors as a result of decreased serum levels of anti-inflammatory cytokines during pregnancy have caused inflammation to play a key role in preeclampsia. The aim of this study was to determine the relationship between interleukin 19 gene polymorphism and the incidence of preeclampsia in pregnant women.

The present descriptive-analytical case-control study was conducted in 2017 at the Islamic Azad University, Kazerun Branch. The statistical population of the study included 300 women referred to Valiasr Hospital of Kazerun, which were devided into two groups: 150 women with preeclampsia were selected as the case and 150 healthy pregnant women were selected as the control. After sampling and DNA extraction, the rs2243191T/C polymorphism was examined by ARMS-PCR method. The collected data were analyzed using chi-square and t-test.

a significant difference was seen in the frequency of CC, CT and TT genotypes (p = 0.05) in the rs2243191T / C polymorphism position of IL-19 gene encoding among pregnant women with Preeclampsia and pregnant women are healthy. There was no significant difference between the two groups in the frequency of C and T alleles (p = 0.208). Apart from seizure parameter (p = 0.003) and patient age (p = 0.015) for other factors measured such as protein excretion in urine, patient inflammation, blood pressure, hypothyroidism, diabetes, history of abortion, History of previous infection, multiplication, primiparous and multiplicity No significant differences were observed between the patient and control groups.

Due to the significant association between rs2243191T/C polymorphism and the occurrence of preeclampsia, the presence of this polymorphism can be considered as a predictor of preeclampsia.