Vaccine-associated Paralytic Poliomyelitis in IRAN A Case Report

For as long as IRAN uses Oral polio vaccine (OPV; Containing live attenuated viruses), for expanded program on childhood immunization. The most severe complication Caused by OPV is Vaccine-associated paralytic poliomyelitis (VAPP). VAPP is more common in people with Immunodeficiency.

Case report: 

The case is an Iranian infant, born on February 21, 2018 and birth weight 2200gr., with cellular immune deficiency. Date of onset of paralysis is 97 days after receiving the second dose of OPV at the age of 7 months on October 2, 2018. Paralysis of the respiratory muscles occurred with tachypnea and fever. According to the world protocol, two stool samples were taken from the patient. The results of both samples with both L20B & RD cell line tests were Positive and vaccine-derived polio virus isolated from the patient's stool. The examinations done by the national referral laboratory of the Tehran University of medical sciences.

A decrease in the Percent of children immunization coverage conduces to circulating Vaccine-Derived Polio Virus (cVDPV) as well as, viral excretion by people with immune deficiency in the community. In addition to cause a poliomyelitis infection in these people, It can endangers the global polio eradication Initiative (GPEI).