Despite the advancement of human science in the field of mental health, it seems that contemporary man has not been freed from many mental disorders such as anxiety, depression and meaninglessness of life. One of the important functions of the divine religions is to create and guarantee mental health. A survey of Islamic texts shows that mental health is of great importance in Islamic teachings. The aim of this study is to answer the question that what are the theological foundations and principles of mental health promotion based on Quranic teachings?  Studying the verses of the Qur'an makes it clear that the pursuit of mental health is based on certain foundations. Characteristics such as two-dimensional human being, attention to the innate human being, monotheistic attitude to health promotion, the lawfulness of the natural world, and consideration of ontology and axiology of disease, are the most important principles of mental health. Such an foundations in mental health according to  the Qur'anic teachings follows special principles and strategies that  consist in : non-corruption in the environment, caring for the body, communication with God, and benevolence to others.