Recent Biological Applications and Chemical Synthesis of Thiohydantoins

Thiohydantoins and their derivatives have attracted enormous attention from researchers worldwide. They represent an important class of compounds within pharmaceutical chemistry and exist in various pharmacologically active molecules that possess significant bioactivities and involved in therapeutic drugs. Additionally, they serve as important intermediates in organic synthesis for the preparation of biologically active compounds. Many compounds from this class were chemically synthesised and tested as potential treatments for various diseases. Herein, this review focuses on the chemical properties, synthesis, and reactions of thiohydantoins with an emphasis on their application in pharmaceutical drugs and in organic synthesis.