The Effect of Diabetes Mellitus on Serum Level of Prostate Specific Antigen

The aim of this study was to assess the effect of diabetes mellitus on Prostate Specific Antigen (PSA) serum levels among diabetic males without urinary tract complaints.

This is a case-control study conducted on 75 diabetic cases and 75 age-matched non-diabetic ones in 2016-17. Patientschr('39') demographics including age, duration of diabetes mellitus, presence of diabetic nephropathy, serum PSA (total and free) were recorded and cases were compared with controls.

Diabetic patients and controls were not statistically different regarding their age (P=0.61). Level of total and free PSA and their ratio were significantly less in diabetic group (P<0.001). Pearson coefficient correlation test showed no statistical association between duration of diabetes mellitus with PSA indices (P>0.05). There was significant association between HbA1C with total and free PSA and their ratio. Insulin therapy was in association with total and free PSA and their ratio (P<0.05) but oral remedies were not (P>0.05).

Diabetic persons have lower levels of all PSA indices. Findings of this study showed inverse statistical association of HbA1C with PSA indices while no association was found with duration of diabetes. PSA indices were significantly lower among patients under insulin therapy but no difference was found considering routine oral therapies.