Association of rs855791TMPRSS6 polymorphism with iron deficiency anemia

According to the relevant studies, among the reported TMPRSS6 polymorphisms associated with iron deficiency anemia, rs855791 has the highest association with hemoglobin level and disease severity. The aim of this study was to investigate the relationship between rs855791and iron deficiency anemia in Sanandaj.

In this case-control study conducted in the Spring of 2016, the frequency of rs855791 polymorphism in TMPRSS6 gene was evaluated in 40 patients with iron deficiency anemia and 80 healthy randomly selected individuals without age and sex restrictions by PCR-RFLP method. Then, the relationship between rs855791  and the level of hemoglobin, ferritin, and MCV in sick and healthy individuals was investigated by SPSS V19 statistical software.

The frequencies of CC, CT, and TT among 40 patients were 15, 37.5, and 47.5 and they were 33.75, 42.5, and 23.75% among 80 healthy controls, respectively. Therefore, there was a significant relationship between TT genotype and disease (p= 0.010). Also, a significant relationship was observed between the frequency of CC and the absence of disease [OR= 0.34, p= 0.035]. The higher frequency of CT in the control group than the indicates a lower risk of people with CT genotype. The results also show a significant relationship between low Hb, MCV, and Ferritin with the genotype so that people with TT genotype had lower Hb, MCV, and ferritin than people with CC and TC genotypes.

TMPRSS6 rs855791 polymorphism was shown to be effective in subject patients with iron deficiency anemia in Sanandaj city.