Evaluation of Changes in the Expression of miR-1193 in Tissue Samples of Patients with Glioblastoma Multiform

Glioblastoma is one of the most malignant cancers worldwide, which due to the difficulty of early diagnosis, most affected people die within a year after diagnosis. Non-coding RNAs are a group of RNAs acting as post-transcriptional regulators and can play an essential role in cancer diagnosis. This study was aimed at investigating the expression level of miR-1193 in glioblastoma multiform and normal tissue samples and their correlation with the grade, age, and sex parameters. In this study, the expression level of miR-1193 was quantified in 50 glioblastoma multiform tissues (at different stages of disease), and 50 normal ones using the Real-Time PCR technique. GraphPad Prism 8 software was used for statistical analysis. The results of this study revealed down-regulation of the miR-1193 glioblastoma multiform samples compared to normal ones. The expression of miR-1193 was not significantly correlated with grade, age, and sex parameters. Finally, increased expression of miR-1193 could play an essential role in glioblastoma multiform. Moreover, according to Roc curve analysis and determining the cut-off value for this biomarker, it was found that the off-cut value was equal to 5.141 for miR-1193, which can detect patients with specificity of 1 and sensitivity of 0.78. However, due to its relatively low sensitivity, more research should be conducted.