The Effect of a Course of Aerobic-resistance Training and Ursolic Acid Consumption on Irisin Levels and Inflammatory Factors in Overweight Middle-aged Men

Gamma-factor progesterone proliferation activating receptors are a ligand-activated transcription factor playing an important role in lipid metabolism. The present study was aimed at evaluating the effect of eight weeks of aerobic-resistance training on the expression of gamma progesterone proliferator-activating receptor gene in patients with coronary artery bypass grafting. The research method was quasi-experimental and pre-test-post-test. The statistical population included all patients with coronary artery bypass grafting in Mashhad (Iran). Height 1.58 ± 0.03 (m), weight 68.11 ± 5.54 (kg), body mass index (BMI) 27.18 ± 2.47 (2 kg / m2) and disease history 75 8.75 ± 25/20 (month) were formed after coronary artery bypass surgery. According to the inclusion criteria, they were divided into experimental (14) and control (12) groups. Data were analyzed using independent t-test and paired t-test at the significance level of P≥0.05 and SPSS software version 21. The results showed that eight weeks of aerobic-resistance training increased the expression of PPARɣ gene in the combined training group compared to the control group (P = 0.001). Moreover, the results of the correlation test showed that the increase in PPAR gene expression in the combined training group had a significant increase in the post-test compared to the pre-test (P = 0.001), not significant in the control group (p = 0.081). The data of the present study showed that aerobic- resistance training with increasing PPARɣ gene expression could be effective in fat metabolism and related processes in patients with coronary artery bypass grafting.