Response of serum levels of Fibroblast Growth Factor-2 and Transforming Growth Factor-β to Eccentric Resistance Training with and without BFR in Active Young Men

Many studies have investigated the response of angiogenesis serum index to eccentric resistance training with blood flow restriction. Therefore, the aim of the present study was to investigate the response of serum levels of fibroblast growth factor (TGFβ) and β - β (FGFβ) growth factor in eccentric resistance training with and without blood flow restriction in young males. 16 healthy males with a mean age of 22.6 ± 7.7 years were randomly selected and divided into two groups of resistance training with low and high intensity training. The exercise group without BFR resulted in the maximum executed 3-5 set of voluntary contraction intensive eccentric resistance exercise, 30, 15, 15, 15, 15 with 45 to 60 second rest interval at 70-80% maximum voluntary contraction, while low intensity resistance exercise with blood flow restriction did the exact previous exercise modality, but with an intensity 20-30% maximum voluntary contraction. The blood sample was taken before and after the exercise intervention from the brachial vein to measure the serum levels of TGF – β and FGF-2 in the with ELISA method. The collected Data analyzed using paired t statistical tests, one way analysis of variance with repeated measurements at P˂0. 05 significant levels. The results show that both resistance training sessions with and without BFR did not change TGF-β FGF-2 in active young men. According to the research findings, it seems that both resistance exercise interventions are not sufficient stimuli to induce enough to change in the stimulatory and inhibitory angiogenesis indicators.