The mechanism of analgesic effect of Salvia macrosiphon methanol extract in formalin model in male rat
There are several reports on the analgesic effects salvia macrosiphon in traditional medicine. In this study the effects of Salvia macrosiphon methanol extracton pain in presence and absence of atropine (muscarinic receptor antagonist )and naloxone (opioid receptor antagonist )were investigated.
In this experimental study , sixty eight mature male Wistar rats with average weight of 180 ± 10g were randomly divided into eight groups of eight each . The methanol extract of Salvia macrosiphon were prepared using percolation method. Various doses of extract (500/1000/2000 mg/ kg i. p ) and sodium salicylate (300 mg/kg i. P) were injected . The analgesic activity was assessed using formalin test in presence and absence of atropine (2mg/kg i. P)and naloxone (1.6mg/kg i. P).
Dose 2000 mg/ kg i. p of Salvia macrosiphon methanol extract and Sodium Salicylate had analgesic effect than control group in formalin test (P<0.05).Also, the analgesic effect of this extract was decreased by atropine and naloxone (P<0.05).
These finding suggest that salvia macrosiphon methanol extract induces its inhibitory effect on pain that may be via muscarinic and opioid receptors.
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