The effect of soy isoflavones on serum concentration of cell adhesion molecules among postmenupausal women: A systematic review and meta-analysis on randomized clinical

New evidence indicates the anti-inflammatory effects of soy isoflavones. The purpose of this study is conducting a systematic review and meta-analysis of clinical trial articles on the effect of soy isoflavones on the serum levels of adhesive molecules in postmenopausal women.

Method and material

In this study, the Clinicaltrials.gov database, ISI web of Science, Cochrane Library, PubMed and Scopus will be searched until December 2020, and all studies that examine soy isoflavones effect on the serum levels of Intracellular Adhesion Molecule 1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), and selectin-E (E-selectin)) has been selected. DerSimonian and Laird random effects model was used to estimate the summary of the overall effects (MDs) and its heterogeneity. Cochranchr('39')s Q test and I-squared statistic were used to compute the statistical heterogeneity of intervention effects.

Three randomized clinical trials on 297 patients investigated the effect of soy isoflavones on serum levels of adhesive molecules in postmenopausal women. The results of meta-analysis showed that taking soy isoflavones supplementation reduced the serum levels of VCAM-1, ICAM-1 and E-selectin by 10.28 ng / ml, 2.11 ng / ml and 13.17 ng / ml, respectively. They were not statistically significant (P> 0.05).

According to the results of this study, soy isoflavones cause a significant decrease in serum levels of ICAM-1, VCAM-1 and E-selectin. However, more studies are needed, with a larger sample size and longer intervention time.