Effect of different exercises on effective factors involved in reverse cholesterol transfer in patients with coronary artery bypass surgery

The present study aimed to compare the effect of different exercises on effective factors involved in reverse cholesterol transfer in patients with coronary artery bypass surgery (CABG).

A number of 45 patients with CABGwere assigned to three groups: control (n=12), aerobic exercise (n=15), and resistance training (n=18). Three aerobic and resistance training sessions were performed per week for eight weeks. Anthropometric variables, expression of ABCG4 gen, as well as the serum levels of Apo-A and Apo-B, were measured before and after the training period. Data were analyzed using repeated measures of ANOVA. A p-value less than 0.05 was considered statistically significant.

Aerobic and resistance training significantly increased the expression of ABCG4 gene, compared to those in the control group (P=0.001); nonetheless, there was no significant difference between the two training groups (P= 0.021). Significant differences were observed in serum levels of Apo-A and Apo-B in both aerobic and resistance training groups, compared to those obtained in the control group (P=0.001). However, the difference between aerobic and resistance training groups was significant for Apo-A (P= 0.001), but not for Apo-B (P=1.000). Moreover, the ratio of Apo-A to Apo-B was significantly different for the resistance training group, compared to that in the control group (P= 0.001); nevertheless, it was not significant for the aerobic training group (P=1.000).

As evidenced by the results of this study, resistance training improves cholesterol reverse transport regulators more than aerobic training; therefore, resistance training is recommended to regulate reverse cholesterol transfer.