Evaluation of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women

Middle-aged women experience changes in bone density due to the transition to menopause. The process of bone measurement and analysis can be continuously controlled by measuring the biochemical markers of bone circulation. Therefore, the aim of this study was to evaluate the status of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women.

A total of 50 active premenopausal women, 46 active menopausal women and 55 active postmenopausal women in the age range of 35-65 years and an average weight of 57.13 kg with medical records and clinical trials were selected and available at Ayatollah Kashani Hospital in Tehran. One-way ANOVA and Scheffe post hoc test were used to examine the differences between the groups and Pearson correlation coefficient was used to find the relationship between the indicators and bone mineral density. Data analysis was performed using SPSS software version 26 (P≤0.05).

The results of the present study showed that the level of mineral density of femoral neck and lumbar vertebrae before menopause was significantly different from during menopause and after menopause (P≤0.05), and the lowest decrease was observed before menopause. Also, serum levels of osteocalcin and bone-specific alkaline phosphatase were significantly increased in both groups during menopause and after menopause (P≤0.01).

The results showed high serum levels of serum osteocalcin and alkaline phosphatase in both menopausal and postmenopausal women. Given that these indicators are one of the main factors determining the premature decrease in bone mineral density in middle-aged women, it can be said that one of the applications of the present study is to use the value of these indicators in predicting bone mineral density and possibly He used these blood variables to identify active women aged 35 to 65 years at risk for osteoporosis.

Middle-aged women experience changes in bone density due to the transition to menopause. The process of bone measurement and analysis can be continuously controlled by measuring the biochemical markers of bone circulation. Therefore, the aim of this study was to evaluate the status of osteoporosis using serum osteocalcin and alkaline phosphatase in active middle-aged women.
 

A total of 50 active premenopausal women, 46 active menopausal women and 55 active postmenopausal women in the age range of 35-65 years and an average weight of 57.13 kg with medical records and clinical trials were selected and available at Ayatollah Kashani Hospital in Tehran. One-way ANOVA and Scheffe post hoc test were used to examine the differences between the groups and Pearson correlation coefficient was used to find the relationship between the indicators and bone mineral density. Data analysis was performed using SPSS software version 26 (P≤0.05).

The results of the present study showed that the level of mineral density of femoral neck and lumbar vertebrae before menopause was significantly different from during menopause and after menopause (P≤0.05), and the lowest decrease was observed before menopause. Also, serum levels of osteocalcin and bone-specific alkaline phosphatase were significantly increased in both groups during menopause and after menopause (P≤0.01).

The results showed high serum levels of serum osteocalcin and alkaline phosphatase in both menopausal and postmenopausal women. Given that these indicators are one of the main factors determining the premature decrease in bone mineral density in middle-aged women, it can be said that one of the applications of the present study is to use the value of these indicators in predicting bone mineral density and possibly He used these blood variables to identify active women aged 35 to 65 years at risk for osteoporosis.