Study of Anticonvulsant Effects of Carbamazepine During Epileptic Process by Unilateral Kindling of CA1 Dorsal Hippocampus in Adult Male Rats

Epilepsy is a chronic and multifactorial disease with recurrent seizures. Carbamazepine is the most common drug used to treat epilepsy. In this research project, the anticonvulsant effects of carbamazepine on the seizure parameters in adult male rats during dorsal hippocampal are investigated epilepsy by electrical kindling method.

This study is experimental. In this study, 49 adult male rats were randomly divided into 7 groups: control, surgical control and drug control, Kindle, drug-Kindle groups. Animals in the Kindle group received daily kindling stimuli rapidly in the CA1 region of the dorsal hippocampus. In the drug-kindle groups (CBZ20K and CBZ40K), 20 mg/kg and 40 mg/kg of carbamazepine were injected before receiving kindling stimuli. In the methylcellulose + kindle (MCK) group, before receiving kindling stimuli, the value 0.2 ml of methylcellulose solution was injected. Seizure intensity indices, duration of after discharge, and duration of seizures were recorded during execution. After words, data analysis concerning seizure behavior was conducted using ANOVA and Kruskal Wallis tests.

The results show that there is a significant difference between the mean seizure severities in comparison between the two groups. However, there is no significant difference between the mean duration of after discharge in the two groups MCK and CBZ40K. In addition, there is no statistically significant difference between the mean duration of seizures in the two groups KND and MCK.

The results show that the effective amount of carbamazepine in the CBZ40K group reduces the severity of seizures, the duration of after discharge and the duration of seizures compared to rats in the KND group.