Evaluation of SIRT1 and PGC-1α gene expression in testicular tissue of azoospermic rats treated with busulfan after a period of swimming training

Azoospermia is defined as the absence of sperm from semen. Spermatogenesis may be highly sensitive to compounds that interfere with mitochondrial energy metabolism and control of cellular respiration. The aim of this study was to evaluate the expression of SIRT1 and PGC-1α genes in testicular tissue of azoospermic rats treated with busulfan after a period of swimming training.

In this experimental study, 20 adult male wistar rats were randomly divided into four groups of healthy control: sham, azoospermia, exercise + azoospermia after azoospermia model was created. Exercise + azoospermia group, one month after azoospermia, performed low-intensity swimming exercises for 8 weeks, five days a week for 30 minutes each day. One-way analysis of variance was used to analyze the data.

The results showed that azoospermia group significantly reduced the expression level of SIRT1 and PGC-1α genes compared to healthy control group and 8 weeks of low intensity aerobic training caused a significant increase in Azoospermia + exercise group compared to azoospermia group. Has been.

In general, the results of the present study indicate that regular aerobic exercise such as low-intensity swimming in controlling the effects of infertility through the maintenance and development of mitochondrial biogenesis helps to improve the process of spermatogenesis.