Preventive effect of Cinamic acid on Rotenon induced pseudo parkisonism in rat

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by progressive loss of midbrain dopaminergic neurons with multifactorial etiologies including age, genetic and environmental factors. The current treatments of the disorder only help reduce symptoms but not stop the disease progression. Morin has been shown to exert neuroprotective and anti-oxidant effects in different models of neurodegenerative diseases. This study aims to investigate the effects of morin on pseudo-parkinsonism induced by perphenazine in rats.

In an experimental study 40 male rats (weight range: 160-200 g) were randomly divided into 5 equal groups (n= 8). In group 1 (Reutononcy 3 mg/kg 48h and in 19 days) group 2 LDOPA (10mg/kg 48h 19days) group 3 (Reutcnonc 3mg/kg 48 h cinamicacid 50mg/kg 48h) group 4 (Reutcnonc 3mg/kg 48h and cinaminacid 100mg/kg 48h) group 5 (Reutcnonc 3mg/kg 48h and cinaminacid 200mg/kg 48h) in 19 days.In all groups The muscle stiffness, using Morpurgo method, rate of catalepsy using Rcaring test, and the amount of Malondialdehyde were avaluoted.

The results of study reported the effectiveness of cinamicacid on improving muscle stiffness and muscle weakness, which it was dose dependent, so that cinamicacid at higher doses was more effective in improving these two complications. Moreover, the results reported the effect of different doses of cinamicacid on the reduction of MDA.