The Effect of Hemodialysis of on Serum Troponin I level in Patients with Renal Disease and Normal Left Ventricular Ejection Fraction

One of the important criteria for acute myocardial ischemia is the level of troponin. The fact that troponin is excreted by the kidneys, and patients under dialysis may have a high level of it, makes the diagnosis of acute ischemia difficult. The present study aimed to evaluate the effect of hemodialysis on serum troponin I level in patients with end-stage renal disease (ESRD) and normal left ventricular ejection fraction (LVEF).

In this cross-sectional study, 106 patients with ESRD and LVEF of more than 50% who underwent hemodialysis during 2018-2019 in Khorshid and Alzahra hospitals in Isfahan, Iran, were studied. The serum levels of troponin I were measured and compared before and after hemodialysis. -

The mean serum level of troponin I was 0.031 ± 0.068 and 0.028 ± 0.036 ng/dl before and after hemodialysis, respectively, with no statistically difference (P = 0.590). The mean difference of troponin level before and after the hemodialysis was 0.003 ± 0.06 ng/ml. Moreover, the changes of troponin levels were not significantly associated with age, sex, duration of dialysis, hemoglobin and hematocrit levels, LVEF, cause of renal failure, and type of underlying disease.

The findings of the present study showed that hemodialysis did not have a significant effect on changes in troponin I levels, and the level of troponin I did not appear to be a suitable biomarker for the expression of cardiovascular disease in hemodialysis patients with normal LVEF.