Survey of Physicochemical Properties of Double Schiff Bases Synthesized by Green Method through Three Component Reactions under Ultrasonic Irradiation

In this research, convenientand environmental friendly method has been reported for preparation of double Schiff bases N,N'-bis(2-hydroxybenzylydene)-1,1-diaminoalkane. These compounds have been synthesized through one pot three component reaction of salicylaldehyde, ammonium hydroxide and various aliphatic aldehydes under ultrasonic irradiation and solvent free conditions. All of desire double Schiff bases obtained with excellent yields and short reaction times using this method. The structure of nine products (4a-i), characterized using different spectroscopy data such as: 1H NMR, 13C NMR, FT-IR and Mass spectrometric. With attention to structure of synthetic double Schiff bases, in continuation of research, physicochemical properties of compounds surveyed using Molinsiration calculating server. As a results, all of the synthetic double Schiff bases obey the Lipinski rules of five and exhibit good absorption, permeability and penetration abilities in human body.