Effects of swimming exercises on FGF23, & Klotho levels, cardiac pathological hypertrophy and cardiac function of male rats CKD

The purpose of this study was to determine the effect of swimming training on pathological cardiac hypertrophy, cardiac function, FGF23 and &Klotho of male rats CKD. In this study, 30 male Wistar rats (7-8 week) were randomly divided into three groups: training, control, and sham. The renal disease model was induced in rats by a 5/6 nephrectomy (5/6-NX) procedure. The exercise protocol was administered incrementally, 2 sessions per week for eight weeks. Activities included warm-up and resistance training. Resistance training was a ladder exercise with 3 sets and 6 repetitions with percentages of body weight. One-way ANOVA and Bonferroni statistical methods were used for data analysis. Significance level was considered P <0.05. The results showed that swimming exercise reduced FGF23 and pathological cardiac hypertrophy but the results were not significant.  Plasma levels of Klotho and cardiac function were significantly increased in the training group compared with the control group. Exercise training significantly decreased serum phosphorus and serum parathormon in the Train group. Serum calcium and vitamin D status were improved but were not significant. Overall, the results showed that swimming exercise can have a significant effect on cardiac function and cardiovascular disease indices in chronic Kidney disease.