The effect of different training periods on beta-amyloid 42 index in hippocampus of streptozotocin-induced diabetic male rats

The aim of the present study was to investigate the effect of different training periods on beta-amyloid 42 index in the hippocampus of streptozotocin-induced diabetic male rats. For this purpose, 84 male Wistar rats weighing 281± 28 g were randomly divided into 4 groups of 21. Subjects were divided into control, exercise, diabetes, diabetes and exercise groups. Simple variance analysis and repeated measures analysis of variance were used to investigate the changes of beta-amyloid 42. The results of analysis of variance in repeated measures showed that there was a significant difference in beta-amyloid 42 at different stages (8, 4 and 12 weeks of training) (P = 0.001). Multiple Bonferroni comparisons revealed that the levels of beta-amyloid 42 were significantly different during all stages of exercise (4 weeks (P = 0.37), 8 weeks (P = 0.001) and 12 weeks (P = 0.001)).In general, it can be concluded that in all 3 different times (4, 8 and 12 weeks) the amount of beta-amyloid 42 in the control and diabetes groups was higher than the exercise, diabetes and exercise groups, respectively. In diabetes, over time (from 4 weeks to 8 and then 12 weeks) the amount of beta-amyloid 42 increases and continuous aerobic training reduces this variable.