Stimulation and Acceleration of Bone Regeneration and Repair Fractures by Biomaterials with Immunomodulatory Properties(A review paper)

One of the issues related to stimulating and accelerating bone regeneration and bone repaired is the role of the immune system in fracture healing, known as osteo-immunology.

In these review 57 articles of science direct and pumped database is investigated for potential role and mechanism of the immune system's response to bone fracture. 

 biological materials such as tumor necrosis factor alpha (TNF-α), lipopolysaccharide (LPS), interleukin-17 (IL-17) protein, lipotic Acid (LTA) could regulates the immune system, which have the ability to improve the ossification process and faster healing.

The direction of future research was predicted regarding the emergence of new therapeutic compounds derived from bone-building materials such as bone growth factors and substances that regulate the behaviour of the immune system in order to regenerate bone.