Association between Serum Omentin-1 Level and Insulin Resistance, Hematological Factors and Gestational Age in Preterm Newborn

Premature birth is one of the most important causes of mortality in the world and is regarded one of the major health problems. In this study, we investigated the relationship of the serum levels of omentin-1with insulin resistance and inflammatory markers in preterm infants.

This study included 32 preterm and 21 full-term newborns. Serum levels of insulin and omentin-1 were measured by ELISA. Fasting blood glucose and C-reactive protein (CRP) were measured with an autoanalyzer. Hematological parameters were measured by Sysmex XS800i analyser.

We found lower levels of serum omentin-1(p<0.001), significantly higher insulin levels and (p = 0.002) and significantly higher insulin resistance (p=0.011) in the preterm infants compared to the full-term infants. Hematologic parameters were not significantly different between the two groups. Serum C-reactive protein (CRP) levels were significantly higher in the preterm infants than in the full-term infants (p<0.001). Omentin-1 levels in the preterm infants showed a significant negative correlation with platelet and white blood cell counts (r =-0.308 and r =-0.306, respectively). Serum omentin-1 level was positively and significantly correlated with gestational age in the preterm infants (r=0.344 and p=0.012). Serum omentin-1 level had a significant negative correlation with serum insulin levels and insulin resistance (r= 0.362 and r=0.229).

Serum omentin-1 was lower in the preterm infants and negatively correlated with inflammatory factors and insulin resistance, and positively related to gestational age.