Simultaneous Effect of Resistance Training and Endothelial Progenitor Cell Injection on Immunoglobulins (Iga, Igm, Igg) In Muscle Tissue of Streptozotocin-Induced Diabetic Rat

Diabetes, as a progressive disease, can lead to decreased immune function. therefore, the aim of this study was to determine the simultaneous effect of resistance training and endothelial progenitor cell injection on immunoglobulins (IgA, IgM, IgG) of streptozotocin-induced diabetic rats.

 30 rats (aged 6 weeks with a mean weight of 200±20 g) were randomly divided into groups including Diabetes + stem cell injection + resistance training (n = 6), diabetes + resistance training (n = 6), diabetes + stem cell injection (n = 6), control diabetes (n = 6) and healthy basal (n = 6) Were divided. Western blotting was used to evaluate the changes in immunoglobulins. Also, two-way analysis of variance was used for comparison between and within the group, and for better understanding of the results, the effect size, and the amount of 95% confidence interval were given.

The results showed that IgA (P = 0.022), IgM (P = 0.017), IgG (P = 0.045) had significant changes between groups. Also, there was a significant difference in all three variables between the control diabetes group and the diabetes + resistance training + injection group (P≤0.05).

Summarizing the results of the present study, it can probably be said that resistance training and simultaneous injection of endothelial progenitor cells improve the status of immunoglobulins by training and injection. These findings suggest that resistance training and injections can be used as a treatment to improve the function of the immune system due to diabetes.