The assesment of morphological changes of ovary and fallopian tube after aplication of Antiprogesterone and Esterogen in the hyperstimulated mice

The ovary is one of the tissues which progesterone receptor is expressed in it. The aim of this study was to investigate the effects of antiprostrogen and estrogen on the ovaries and fallopian tubes of ovulated stimulated mice.

In this study, mice were divided into four groups after stimulation of ovulation and pregnancy. 1) Control 2) Estrogen, 3) Progesterone, 4) Anti-progesterone and estrogen. 4.5 days after pregnancy, mice were killed by cervical vertebral disslocation and the ovaries and fallopian tubes were prepared by H&E and PAS staining for histomorphometrical changes.

The results showed that there were different types of follicles and corpus luteum in the control group. In the progesterone group, the number of corpus luteum increased compared to the control group and in the estrogen group, The corpus luteum decreased and the majority of follicles were primitive or growing. The amount of atretic follicles was higher in the anti-progesterone with estrogen group. The results obtained from the fallopian tubes indicate that progesterone injection reduces the height of the luminal epithelium and the number of ciliated cells. In the estrogen-containing groups, an increase in ciliated cells and epithelial height were observed.

The results of this study showed that progesterone alone could not provide better conditions for fertilization and adding estrogen to progesterone may improve this condition.