The effect of resistance training on serum amyloid A protein levels and insulin resistance in sedentary obese women

Serum amyloid A (SAA) is an inflammatory factor which has an important role in pathogenesis of insulin resistance. Aim of present study was to investigate the effect of 12 weeks resistance training on serum amyloid A protein levels and insulin resistance in sedentary obese women.

24 sedentary obese women aged 20 to 35 years old assigned to control (12 person) and resistance training (12 person) groups. Resistance training program completed during 12 weeks/ three sessions per week with 75 percent of 1 repetition maximum (1RM) and four sets with 8-12 repetitions. Before starting training program and two days after last training session, blood samples collected and SAA, glucose and insulin levels were measured. Present findings analyzed with SPSS software version 24. Analysis of covariance test were used for comparing groups changes, and intra-group changes determined using paired t test.

According to study findings, serum levels of SAA in resistance training program group compared to control group significantly decreased (p=0.015). In addition, significant decrease in insulin resistance in resistance training group compared to control group was observed (p=0.001). Intra-group analysis represented a significant decrease in SAA levels in the resistance training group (p=0.048) and non-significant changes in the control group (p=0.389).

The resistance training program leads to the improvement of insulin resistance in obese women by reducing the levels of inflammatory factors such as SAA. Nevertheless, identifying the mechanisms of reducing SAA levels by exercise training requires further investigation.