Effect of eight weeks swimming exercise training on VEGF-A and FGF-2 of hippocampus tissue and Lee's index in male wistar rats

The increase of proteins related to blood supply in the hippocampus tissue following swimming exercise can probably prevent the occurrence of brain diseases such as Alzheimer's. The aim of the present study was to determine the effect of eight weeks swimming exercise training on VEGF-A and FGF-2 levels of hippocampus tissue and Lee's Index in male Wistar Rats.

16 male Rats, divided randomly into 2 groups (swimming exercise training and control). Swimming training group exercised for 8 weeks, 5 consecutive days per week for 60 minutes in water with 32±2˚C of temperature. for evaluation of VEGF-A and FGF-2 Levels used from Elisa Method, To measure Lee's index from height and weight measurements and for hypothesizes test used from Independent T Student, Mann - Whitney U and Wilcoxon tests in level of p≤0.05.

Results show that eight weeks swimming training cause significant increase in VEGF-A (P=0.002) and FGF-2 (P=0.000) in hippocampus tissue compare to control group. Furthermore Eight weeks Swimming training cause significant decrease in Lee's index and improvement of mass index in Rats (P=0.012).

Results of this study show that eight weeks swimming exercise training cause increase on effective angiogenic factors in hippocampus tissue and improvement of mass index in male Wistar Rats