The Effect of Ofloxacin on Prostate Specific Antigen Level in Men with High Antigen

 Prostate cancer is one of the most common visceral cancers in men. One of the methods used for early diagnosis of this disease and before its symptoms appear is screening with the help of prostate specific antigen measurement. Another factor that increases prostate specific antigen is prostate infections. Therefore, the aim of the present study was to determine the effect of ofloxacin on the amount of prostate specific antigen in men with high antigen. 

In the present descriptive-analytical study conducted in 2019, 224 men with specific antigen higher than 4 nanograms were evaluated by administering 200 mg of ofloxacin every 12 hours for 10 days. Exclusion criteria included age less than fifty or more than 75 years, history of sensitivity to fluoroquinolones, history of recent prostate manipulation, use of 5-alpha reductase inhibitors, and known cases of prostate cancer. After ten days of taking the drug, the prostate specific antigen was measured for the second time and the results were evaluated using vital statistics tests. In all patients, a complete urine test and prostate examination were performed through the intestine. The collected data were analyzed using Chi-square statistical tests.

 The average age of the patients was 61.18 years and the average antigen level before antibiotic administration was 26.3 (21.9±97.4). In 120 patients (53.57%) after taking antibiotics, the antigen level decreased to a certain extent, which eliminated the need for biopsy, and in the remaining patients, biopsy was performed, and 65 cases of prostate cancer and 39 cases of benign prostatic hyperplasia were reported. In 114 patients (50.89%), pyuria was shown in the urine test.

The present study indicated that in a patient who has active urine (pyuria) and the prostate examination is normal, it is possible to delay the decision on prostate biopsy and start antibiotics for the patient. Moreover, if there was a significant drop in the amount of antigen, the patient continued taking antibiotic and avoided unnecessary biopsy. Otherwise, antibiotics are useless in an asymptomatic patient with a complete urine test that is normal, but with high antigen.