Preventive effects of ondansetron on hypotension following spinal anesthesia in women candidates for elective caesarean section: a systematic review and meta-analysis

Since the prevention of hypotension following spinal anesthesia in women candidates for caesarean section is more important than other surgeries, accurate and comprehensive information in this field is necessary and essential. Therefore, the present study was conducted with the aim of preventive effects of ondansetron on blood pressure drop following spinal anesthesia in women candidates for elective cesarean section.

This study is a systematic review and meta-analysis by searching the keywords hypotension, spinal anesthesia, ondansetron, prevention, cesarean delivery in PubMed, Google Scholar, Cochrane, Scopus, Web of Science, EMBASE and CINAHL databases. Iran and SID were done.

9 clinical trial articles with the participation of 1506 women were included in this meta-analysis; The results indicated that the preventive administration of ondansetron before the start of spinal anesthesia significantly reduces the prevalence of hypotension following spinal anesthesia (RR=0.51, 0.35-0.76, 95%CI- P =0.0008 ) so that in 24% of the patients in the ondansetron group and in 49% of the patients in the control group, blood pressure drop occurred after spinal anesthesia.

Prophylactic administration of ondansetron before spinal anesthesia in women candidates for elective caesarean section leads to a decrease in the incidence of hypotension following spinal anesthesia.