The Effect of Eight weeks of Interval Training on plasma levels of Sirt1 and Sirt3 Proteins in Inactive Elderly Men

 SIRT proteins are involved in the body's metabolic processes and homeostasis and are associated with oxidative stress due to aging and age-related diseases. Changes in these proteins in aging and the effect of physical activity on them have been less studied, so the aim of the present study was to investigate the effect of eight weeks of interval training on plasma levels of sirt1 and sirt3 proteins in inactive elderly men.

 In this study, 20 inactive elderly men aged 70-60 years were selected by available sampling and divided into experimental and control groups by simple random sampling. To investigate the effect of aging on plasma levels of Sirt1 and Sirt3 proteins, 10 inactive young men were selected by purposive sampling. The training program consisted of eight weeks of interval training with a moderate intensity of 50% of the reserve heart rate based on the principle of overload. Plasma levels of Sirt1 and Sirt3 proteins were measured in two stages of pre-test and post-test. One-way analysis of variance (ANOVA) was used to compare the pre-test of the three groups and the analysis of covariance was used to compare the post-test of the two groups of training elderly and control elderly.

 The results showed that plasma levels of Sirt1 and Sirt3 proteins in the elderly group were significantly lower than the young group (P <0.05). Also, due to eight weeks of interval training, the levels of the above proteins increased significantly (P <0.05).

According to the results of this study, it seems that  moderate interval exercise with increasing the Sirt1 and Sirt3 proteins, can reduce the oxidative stress caused by aging and lead to increased antioxidant defense and improve the quality of life in the elderly.