Evaluation of changes in blood antioxidants in dogs with parvovirus infection

Canine parvovirus (CPV-1) is a highly contagious viral disease in dogs that usually causes acute gastrointestinal disease in puppies. The disease is more common in dogs aged 6 weeks to 6 months. Antioxidants are compounds that prevent oxidation. Oxidation is a chemical reaction that can produce free radicals, thus leading to chain reactions that may damage the cells of living organisms. Antioxidants such as thiol or ascorbic acid (vitamin C) interrupt these chain reactions. Due to the prevalence of parvovirus in dogs and little research on the effect of antioxidants in controlling or exacerbating the disease, this study was performed to determine the effect of antioxidants in the treatment of this disease. In this study, blood samples were taken from 50 dogs, including 25 dogs with parvovirus disease and 25 healthy dogs with the disease, followed by catalase, glutathione peroxidase, superoxide dismutase, malondialdehyde and total antioxidant capacity. Rendox kit spectrophotometry was measured. Statistical results to t-test method and SPSS software version 23 were analyzed. The results showed that the enzymes of catalase, glutathione peroxidase, superoxide dismutase and total antioxidant capacity in the treatment group compared to the control group had a statistically significant decrease and the amount of malondialdehyde increased statistically (P <0.05). The results show that dogs with parvovirus infection are affected by the antioxidant system, so it should be considered in treatment and prevention.