Association between ICB-1 Gene Polymorphism rs1467465 (A>G) and Thyroid Cancer Susceptibility

Studies indicate that single nucleotide polymorphism of ICB-1 gene rs1467465 is associated with breast cancer and ovarian cancer. This study was conducted with the aim of investigating the association between ICB-1 gene polymorphism rs1467465 (A>G) and thyroid cancer susceptibility.

In this case-control study, the peripheral blood of 92 thyroid cancer patients referred to Tabriz hospitals and 203 healthy individuals were prepared. After DNA extraction by saturated salt solution, single nucleotide polymorphism rs1467465 of ICB-1 gene was investigated by TETRA-ARMS-PCR method. Then, allelic and genotypic frequencies of patient and control groups were evaluated and compared.

In this study, the genotypic frequency of AA, AG and GG in the patient group was 4.34%, 68.47% and 27.17%, respectively, and in the control group was 4.92%, 55.66% and 39.40% respectively. The frequencies of A and G alleles were calculated as 38.58% and 61.41% in the patient group and 32.75% and 67.24% in the control group, respectively. In this study, the relationship between this polymorphism and some clinical and pathological characteristics of thyroid cancer, including gender, age, type, grade and size of tumor, involvement of lymph nodes and involved side, was investigated.

This study showed that AG and GG genotypes have a significant relationship with the risk of developing thyroid tumors in the studied population, and this polymorphism may contribute to determining the relative risk of developing thyroid tumors.