The effect of combined administration of Onsoli syrup and Samgh capsule (Persian Medicine Products) on clinical and laboratory symptoms in women with polycystic ovary syndrome (A pilot study)

Polycystic ovary syndrome (PCOS) is the most common cause of oligomenorrhea and anovulation in women referring with infertility. The present study was performed aimed to investigate the effect of combined administration of Onsoli syrup and Samgh capsule on clinical and laboratory symptoms in women with PCOS.

This pilot study is a pre-and post-clinical study without control group which was performed in 2019 on 20 women aged 17-45 years with PCOS complaining of oligomenorrhea in Persian Medicine Clinic of Shahid Beheshti University of Medical Sciences. Samgh capsule and Tonic Onsoli syrup were used for two months. Anthropometric indexes, endometrial thickness, ovarian size, hormonal evaluation, number of menstruation per month, menstrual duration, and volume of menstruation bleeding were evaluated and compared at the beginning and end of the study. Data were analyzed by SPSS software (version 23) and paired t-test and Wilcoxon test. P<0.05 was considered statistically significant.

There was no significant difference in body mass index, body fat mass, waist to hip ratio, endometrial thickness, left ovarian size, FSH, LH before and after treatment (p>0.05). The size of the right ovary and testosterone levels significantly deceased after treatment (p=0.02). The number of menstruation per month significantly increased from 0.35±0.18 to 0.92±18 (p=0.00). Also, the duration of menstruation significantly decreased from 7.53±2.43 days to 4.05±3.17 days (p=0.00). The volume of mensuration bleeding decreased from 33.40±15.28 ml to 31.07±10.05 ml, which was not significant (p=0.368).

Due to the effectiveness of combined administration of Persian medicine products (Onsoli syrup and Samgh capsule), it seems that the use of these products is effective in controlling of the symptoms of PCOS. It is necessary to conduct future studies with a larger sample size and longer evaluation time.